Alwin Krämer Selected Research

Griseofulvin (Grifulvin V)

4/2017	Synthesis and formulation studies of griseofulvin analogues with improved solubility and metabolic stability.
10/2012	GF-15, a novel inhibitor of centrosomal clustering, suppresses tumor cell growth in vitro and in vivo.
1/2012	Disparate SAR data of griseofulvin analogues for the dermatophytes Trichophyton mentagrophytes, T. rubrum, and MDA-MB-231 cancer cells.
5/2009	Synthesis and structure-activity relationship of griseofulvin analogues as inhibitors of centrosomal clustering in cancer cells.

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Alwin Krämer Research Topics

Disease

32	Neoplasms (Cancer) 06/2022 - 11/2003
22	Acute Myeloid Leukemia (Acute Myelogenous Leukemia) 01/2022 - 06/2011
6	Leukemia 01/2020 - 08/2011
4	Infections 08/2022 - 01/2013
4	Neoplasm Metastasis (Metastasis) 11/2021 - 04/2016
3	Chromosome Aberrations (Chromosome Abnormalities) 01/2022 - 04/2009
3	Carcinoma (Carcinomatosis) 11/2021 - 01/2021
3	Disease Progression 11/2021 - 02/2015
3	Multiple Myeloma 01/2021 - 04/2009
3	Fever (Fevers) 01/2019 - 08/2014
3	Microcephaly 03/2012 - 06/2009
3	Breast Neoplasms (Breast Cancer) 01/2012 - 11/2003
2	Nausea 03/2022 - 01/2019
2	Chromothripsis 01/2022 - 01/2017
2	Microsatellite Instability 01/2022 - 01/2021
2	Acute Promyelocytic Leukemia 12/2021 - 09/2016
2	Pneumonia (Pneumonitis) 01/2019 - 12/2015
2	Sepsis (Septicemia) 01/2019 - 02/2010
2	Myelodysplastic Syndromes (Myelodysplastic Syndrome) 12/2018 - 01/2018
2	Tetraploidy 09/2012 - 04/2007
1	COVID-19 08/2022
1	Tumor Lysis Syndrome 03/2022
1	Hypokalemia 01/2021
1	Body Weight (Weight, Body) 01/2021
1	Hypocalcemia 01/2021
1	Febrile Neutropenia 01/2019
1	Septic Shock (Toxic Shock Syndrome) 01/2019
1	Precursor Cell Lymphoblastic Leukemia-Lymphoma (Acute Lymphoblastic Leukemia) 09/2018
1	Kidney Neoplasms (Kidney Cancer) 05/2018
1	Carcinogenesis 01/2018
1	Inflammation (Inflammations) 04/2016
1	T-Cell Lymphoma (Lymphoma, T Cell) 04/2016

Drug/Important Bio-Agent (IBA)

8	Proteins (Proteins, Gene)FDA Link 01/2021 - 04/2007
4	DNA (Deoxyribonucleic Acid)IBA 11/2021 - 11/2003
4	quizartinibIBA 01/2021 - 01/2019
4	Griseofulvin (Grifulvin V)FDA LinkGeneric 04/2017 - 05/2009
3	Pharmaceutical PreparationsIBA 03/2022 - 01/2018
3	ParaffinIBA 12/2019 - 12/2012
3	RNA (Ribonucleic Acid)IBA 09/2019 - 03/2004
3	Sorafenib (BAY 43-9006)FDA Link 12/2015 - 06/2012
3	TubulinIBA 01/2012 - 11/2003
3	pericentrinIBA 06/2009 - 11/2003
2	Biomarkers (Surrogate Marker)IBA 01/2022 - 11/2018
2	Paclitaxel (Taxol)FDA LinkGeneric 01/2021 - 01/2019
2	Carboplatin (JM8)FDA LinkGeneric 01/2021 - 01/2019
2	Protein-Tyrosine Kinases (Tyrosine Kinase)IBA 01/2021 - 09/2016
2	Core Binding Factors (Core-Binding Factor)IBA 01/2020 - 01/2017
2	Formaldehyde (Formol)FDA Link 12/2019 - 09/2019
2	Azacitidine (5 Azacytidine)FDA Link 12/2018 - 08/2014
2	MethyltransferasesIBA 12/2017 - 07/2014
2	Cytarabine (Cytosar-U)FDA LinkGeneric 08/2014 - 07/2011
2	Messenger RNA (mRNA)IBA 06/2011 - 03/2011
2	Complementary DNA (cDNA)IBA 04/2007 - 03/2004
1	Anti-Bacterial Agents (Antibiotics)IBA 08/2022
1	BilirubinIBA 03/2022
1	Aspartate Aminotransferases (Aspartate Transaminase)IBA 03/2022
1	Alanine Transaminase (SGPT)IBA 03/2022
1	isocitric acid (isocitrate)IBA 01/2022
1	Biological ProductsIBA 01/2022
1	Arsenic Trioxide (Trisenox)FDA Link 12/2021
1	Tretinoin (Retinoic Acid)FDA LinkGeneric 12/2021
1	Tyrosine (L-Tyrosine)FDA Link 01/2021
1	PlatinumIBA 01/2021
1	Phosphoprotein Phosphatases (Phosphatases, Protein)IBA 01/2021
1	bis(3- bis(4- chlorophenyl)methyl- 4- dimethylaminophenyl)amineIBA 01/2021
1	AmanitinsIBA 01/2021
1	B7-H1 AntigenIBA 01/2021
1	RNA Polymerase II (RNA Polymerase B)IBA 01/2021
1	Cetuximab (Erbitux)FDA Link 01/2021
1	Immunoconjugates (Immunoconjugate)IBA 01/2021
1	fms-Like Tyrosine Kinase 3IBA 12/2020
1	Core Binding Factor Alpha 2 SubunitIBA 01/2020
1	Adenosine Monophosphate (AMP)IBA 09/2019
1	Cisplatin (Platino)FDA LinkGeneric 01/2019
1	Gemcitabine FDA Link 01/2019
1	enasidenibIBA 01/2018
1	Histones (Histone)IBA 01/2018
1	Lysine (L-Lysine)FDA Link 12/2017
1	Antifungal AgentsIBA 04/2017
1	Genetic Markers (Genetic Marker)IBA 01/2017
1	Becaplermin (PDGF-BB)FDA Link 11/2016
1	Actin Depolymerizing Factors (Cofilins)IBA 11/2016
1	Mitogen-Activated Protein Kinase Kinases (MEKs)IBA 11/2016
1	Retinoic Acid Receptor alphaIBA 09/2016
1	NAD (NADH)IBA 04/2016
1	LipidsIBA 04/2016
1	Keratins (Keratin)IBA 04/2016
1	EnzymesIBA 04/2016
1	CholesterolIBA 04/2016
1	5' Untranslated Regions (5' UTR)IBA 04/2016
1	Inwardly Rectifying Potassium Channels (Inward Rectifier Potassium Channels)IBA 04/2016

Therapy/Procedure

13	Drug Therapy (Chemotherapy) 06/2022 - 07/2007
10	Therapeutics 12/2021 - 05/2010
6	Stem Cell Transplantation 12/2018 - 08/2011
2	Radiotherapy 11/2021 - 05/2018
1	Artificial Respiration (Mechanical Ventilation) 08/2022
1	Hematopoietic Stem Cell Transplantation 01/2021
1	Immunotherapy 01/2021
1	Cell Transplantation 01/2020
1	Aftercare (After-Treatment) 12/2018